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KMID : 0861020080230040059
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Korea Journal of Herbology
2008 Volume.23 No. 4 p.59 ~ p.70
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Antidepressant Effects of Citri Reticulatae Viride Pericarpium in the Forced Swimming Test
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Kwon Yong-Uk
Lee Tae-Hee
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Abstract
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Objectives: Investigation of the antidepressant effects of Citri Reticulatae Viride Pericarpium(CR)
Methods: In order to investigate the antidepressant effects of Citri Reticulatae Viride Pericarpium(CR), we performed the forced swimming test. Also the expression of CRF, HSP70 and c-fos was measured with immunohistochemical method at PVN.
Results: 1. The duration of immobility in the forced swimming test was significantly decreased in the CR 100mg/kg, 400mg/kg groups. 2. In the Control group, CRF expression was significantly increased in the PVN. Also, these CRF increase were significantly reduced in the CR 100mg/kg and 400mg/kg treated group. 3. HSP70 expression was significantly decreased at PVN in the CR 100mg/kg and 400mg/kg treated group. 4. C-fos expression was significantly decreased at PVN in the CR 100mg/kg and 400mg/kg treated group.
Conclusions: According to the results, it can be considered that Citri Reticulatae Viride Pericarpium has antidepressant effect.
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KEYWORD
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Citri Reticulatae Viride Pericarpium, FST, CRF, HSP70, c-fos, PVN
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